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Associate Professor,
Department of Biological Sciences


Research in the laboratory focuses on the unrestrained intracellular protein trafficking events that occur in cancer and diabetes diseases. Our current work centers on activators of the Rab5 small GTP-ases and their potential connection with activated Receptor Tyrosine Kinase (also knows as Signaling Receptor). We have identified a novel mechanism that integrates Rab5 activation with several Signaling Receptors and are currently examining the precise role of this novel mechanism in regulating cell surface receptor trafficking and cell signaling in normal and disease states.

  • Molecular mechanism of Rab5-mediated endosome fusion driven by growth factors and hormones
  • Role of Rab5 associated nucleotide exchange factors (i.e., Rin1, Rabex-5, RAP-6) in Receptor Tyrosine Kinase (RTK)-mediated signal transduction and cell differentiation
  • Regulatory mechanisms that control the activity of Rab5 associated nucleotide exchange factors during phagocytosis.


Please visit the following link to view Dr. Barbieri’s current projects



Alejandro Barbieri

11200 SW 8th St, AHC1 318 C

Miami, FL 33199 – 305-348-7535

FIU International Center for Tropical Botany